subspecies

Tričković et al. develop a comprehensive genomic human gut microbiota subspecies catalog by defining operational subspecies units (OSUs) in an unbiased, cohort-independent manner. Panhashome, a sketching-based method, enables rapid OSU quantification and identification of genes driving intraspecies variations. A subspecies-based machine-learning CRC diagnostic algorithm outperforms species-level methods by leveraging subspecies-level information.

Talk title: Decoding the Microbial Universe: Large-Scale Metagenomics at the Sub-Species Level